I found that things became much more pleasant on here when I blocked hexbear. I recently blocked lemmy.ml as well, but I may reverse that if I find that I’m missing too much good content.
I’m open to other ideas on how to mostly avoid people who love conflict or argue in bad faith.
I want to block the users as a group even if the instance at which I am registered does not defederate.
Some apps let you do that. Sync, for example, let’s you block instances (users included) on the client side.