Answer
Sign Language.
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Here is a fun addition to this – in the year 2010, Boa Sr died. She was the last speaker of the Bo language - one of the ten Great Andaman languages.
So, in our lifetime, there was a language from this area that went from “1” speaker left to “0.”
I would assume that there are a few tribal languages out there somewhere that have less than 100 though I couldn’t name them.
Oddly enough, just came across a one speaker language in my Twitter just now.