DEIR AL-BALAH, Gaza Strip — Israeli strikes across Gaza killed 28 people overnight and into Sunday, including young quadruplets, local health officials said, as U.S. Secretary of State Antony Blinken headed to the region to try to seal a cease-fire deal after months of negotiations.

The U.S. and fellow mediators Egypt and Qatar said they were closing in on a deal after two days of talks in Doha, with American and Israeli officials expressing cautious optimism. But Hamas has signaled resistance to what it says are new demands by Israel, and the long-running talks have repeatedly stalled.

The evolving proposal calls for a three-phase process in which Hamas would release all hostages abducted during its Oct. 7 attack, which triggered the deadliest war ever fought between Israelis and Palestinians. In exchange, Israel would withdraw its forces from Gaza and release Palestinian prisoners.